壹生大学

壹生身份认证协议书

本项目是由壹生提供的专业性学术分享,仅面向医疗卫生专业人士。我们将收集您是否是医疗卫生专业人士的信息,仅用于资格认证,不会用于其他用途。壹生作为平台及平台数据的运营者和负责方,负责平台和本专区及用户相关信息搜集和使用的合规和保护。
本协议书仅为了向您说明个人相关信息处理目的,向您单独征求的同意,您已签署的壹生平台《壹生用户服务协议》和《壹生隐私政策》,详见链接:
壹生用户服务协议:
https://apps.medtrib.cn/html/serviceAgreement.html
壹生隐私政策:
https://apps.medtrib.cn/html/p.html
如果您是医疗卫生专业人士,且点击了“同意”,表明您作为壹生的注册用户已授权壹生平台收集您是否是医疗卫生专业人士的信息,可以使用本项服务。
如果您不是医疗卫生专业人士或不同意本说明,请勿点击“同意”,因为本项服务仅面向医疗卫生人士,以及专业性、合规性要求等因素,您将无法使用本项服务。

同意

拒绝

同意

拒绝

知情同意书

同意

不同意并跳过

工作人员正在审核中,
请您耐心等待
审核未通过
重新提交
完善信息
{{ item.question }}
确定
收集问题
{{ item.question }}
确定
您已通过HCP身份认证和信息审核
(
5
s)

2025 ASCO专场前瞻丨乳腺癌领域口头报告专场研究速览

2025-05-12作者:论坛报晶资讯
原创

image.png

2025年美国临床肿瘤学会(ASCO)年会即将于5月30日至6月3日在美国芝加哥正式召开。作为全球肿瘤学领域规模最大、最具影响力的学术盛会之一,本届年会以“知识化为行动:共创美好未来(Driving Knowledge to Action: Building a Better Future)”为主题,汇聚全球肿瘤领域权威专家,共同探讨癌症治疗的最新突破与临床实践创新。


为帮助读者提前了解会议亮点、高效参会,“2025 ASCO年会中国医学论坛报学术联播”带您一览2025 ASCO年会中乳腺癌领域重要口头报告及快速口头报告信息以下是口头报告专场各项研究速览,中国团队研究已用“⭐️⭐️⭐️”重点标出。


口头报告专场
Oral Abstract Session


01
转移性乳腺癌
Breast Cancer—Metastatic
摘要号: LBA1000

英文标题:Vepdegestrant, a PROTAC estrogen receptor (ER) degrader, vs fulvestrant in ER-positive/human epidermal growth factor receptor 2 (HER2)–negative advanced breast cancer: Results of the global, randomized, phase 3 VERITAC-2 study


中文标题:Vepdegestrant[一种PROTAC雌激素受体(ER)降解剂]对比氟维司群用于ER+/人表皮生长因子受体2(HER2)-晚期乳腺癌:全球随机Ⅲ期VERITAC-2研究结果


讲者:Erika P. Hamilton, MD | Breast Cancer Research Program, Sarah Cannon Research Institute


摘要号:  1001

文标题:Patient-reported outcomes (PROs) in patients with ER+, HER2- advanced breast cancer (ABC) treated with imlunestrant, investigator’s choice standard endocrine therapy, or imlunestrant + abemaciclib: Results from the phase III EMBER-3 trial


中文标题:ER+/HER2-晚期乳腺癌(ABC)患者接受imlunestrant、研究者选择的标准内分泌治疗或imlunestrant联合abemaciclib的患者报告结局(PROs):Ⅲ期EMBER-3试验结果


讲者:Giuseppe Curigliano, MD, PhD | Istituto Europeo di Oncologia, IRCCS, University of Milano


摘要号: 1003

文标题:INAVO120: Phase III trial final overall survival (OS) analysis of first-line inavolisib (INAVO)/placebo (PBO) + palbociclib (PALBO) + fulvestrant (FULV) in patients (pts) with PIK3CA-mutated, hormone receptor-positive (HR+), HER2-negative (HER2–), endocrine-resistant advanced breast cancer (aBC)


中文标题:Ⅲ期INAVO120试验最终总生存(OS)期分析:inavoisib(INAVO)/安慰剂(PBO) +哌柏西利(PALBO)+氟维司群(FULV)一线治疗PIK3CA突变的内分泌耐药的HR+/HER2-晚期乳腺癌患者


讲者:Nicholas C. Turner, MD, PhD | Royal Marsden Hospital and Institute of Cancer


摘要号: 1004

文标题:Phase I/Ib study of inavolisib (INAVO) alone and in combination with endocrine therapy ± palbociclib (PALBO) in patients (pts) with PIK3CA-mutated, hormone receptor–positive, HER2-negative locally advanced/metastatic breast cancer (HR+, HER2– LA/mBC): Analysis of hyperglycemia (HG) in prediabetic/obese pts


中文标题:Inavolisib(INAVO)单药及联合内分泌治疗±哌柏西利(PALBO)治疗PIK3CA突变、HR+/HER2–局部晚期/转移性乳腺癌的I/Ib期研究:糖尿病前期/肥胖患者的高血糖(HG)分析


讲者:Mafalda Oliveira, MD, PhD | Vall d'Hebron University Hospital and Vall d'Hebron Institute of Oncology (VHIO)


摘要号: LBA1005

文标题:A double-blind placebo controlled randomized phase III trial of fulvestrant and ipatasertib as treatment for advanced HER2-negative and estrogen receptor positive (ER+) breast cancer following progression on first line CDK 4/6 inhibitor and aromatase inhibitor: The CCTG/BCT MA.40/FINER study (NCT04650581)


中文标题:氟维司群联合ipatasertib对比安慰剂治疗一线CDK4/6抑制剂和芳香酶抑制剂进展后的晚期HER2-/ER+乳腺癌的Ⅲ期双盲随机试验:CCTG/BCT MA.40/FINER研究(NCT04650581)


讲者:Stephen K. L. Chia, MD, FRCPC | BC Cancer Agency


摘要号:  1007

文标题:Phase III of oral paclitaxel (DHP107) vs intravenous paclitaxel in HER2-negative recurrent or metastatic breast cancer (mBC): Primary analysis of a multinational optimal trial (NCT03315364)


中文标题:口服紫杉醇(DHP107)对比静脉紫杉醇治疗HER2-复发或转移性乳腺癌(mBC)的Ⅲ期研究:跨国优化试验(NCT03315364)的主要分析


讲者:Sung-Bae Kim, MD | Asan Medical Center, University of Ulsan College of Medicine


摘要号: 1013

文标题:Exploratory biomarker analysis of trastuzumab deruxtecan (T-DXd) vs physician’s choice of chemotherapy (TPC) in HER2-low/ultralow, hormone receptor–positive (HR+) metastatic breast cancer (mBC) in DESTINY-Breast06 (DB-06)


中文标题:DESTINY-Breast06(DB-06)研究中,trastuzumab deruxtecan(T-DXd)对比医师选择化疗(TPC)治疗HER2低/超低表达、HR+转移性乳腺癌的探索性生物标志物分析


讲者:Rebecca Alexandra Dent, MD, FASCO | National Cancer Centre Singapore


摘要号:  LBA109

文标题:Sacituzumab govitecan (SG) + pembrolizumab (pembro) vs chemotherapy (chemo) + pembro in previously untreated PD-L1–positive advanced triple-negative breast cancer (TNBC): Primary results from the randomized phase 3 ASCENT-04/KEYNOTE-D19 study


中文标题:Sacituzumab govitecan(SG)+帕博利珠单抗(pembro)对比化疗(chemo)+帕博利珠单抗用于初治PD-L1+晚期TNBC:Ⅲ期ASCENT-04/KEYNOTE-D19研究主要结果


讲者:Sara M. Tolaney, MD, MPH, FASCO | Dana-Farber Cancer Institute and Harvard Medical School


02
乳腺癌——局部/区域/辅助治疗

Breast Cancer—Local/Regional/Adjuvant

⭐️⭐️⭐️摘要号:  LBA500

英文标题:De-escalated neoadjuvant taxane plus trastuzumab and pertuzumab with or without carboplatin in HER2-positive early breast cancer (neoCARHP): A multicentre, open-label, randomised, phase 3 trial


中文标题:降阶梯紫杉类+曲妥珠单抗帕妥珠单抗联合或不联合卡铂新辅助治疗HER2+早期乳腺癌(neoCARHP):一项多中心、开放标签、随机Ⅲ期试验


讲者:王坤,广东省人民医院


摘要号: 501

文标题:Predicting pathologic complete response (pCR) from clinicopathologic variables and HER2DX genomic test in stage II/III HER2+ breast cancer treated with taxane, trastuzumab, and pertuzumab (THP): Secondary results from the EA1181/CompassHER2 pCR trial


中文标题:基于临床病理变量和HER2DX基因组检测预测Ⅱ/Ⅲ期HER2+乳腺癌接受紫杉类+曲妥珠单抗+帕妥珠单抗(THP)治疗的病理学完全缓解(pCR)率:EA1181/CompassHER2 pCR试验的次要结果


讲者:Nadine M. Tung, MD, FASCO | Beth Israel Deaconess Medical Center


摘要号: 502

英文标题:Prediction of survival after de-escalated neoadjuvant therapy in HER2+ early breast cancer: A pooled analysis of three WSG trials


中文标题:HER2+早期乳腺癌降阶梯新辅助治疗后生存预测:三项WSG试验的汇总分析


讲者:Monika Karla Graeser, MD | West German Study Group and Ev. Hospital Bethesda, Breast Center Niederrhein, Moenchengladbach, Germany and Department of Gynecology, University Medical Center Hamburg


摘要号: 503

英文标题:Comparison of marking techniques for target lymph nodes in 2,596 patients with node-positive breast cancer treated with neoadjuvant chemotherapy: Results from the prospective multicenter AXSANA/EUBREAST-03/AGO-B-053 study 


中文标题:2596例淋巴结阳性乳腺癌新辅助化疗患者靶向淋巴结标记技术的比较:前瞻性多中心AXSANA/EUBREAST-03/AGO-B-053研究结果


讲者:Maggie Banys-Paluchowski, PhD | Department of Obstetrics and Gynecology, University Hospital of Schleswig Holstein, Campus Lübeck


摘要号: 505

英文标题:15-year outcomes for women with premenopausal hormone receptor-positive early breast cancer (BC) in the SOFT and TEXT trials assessing benefits from adjuvant exemestane (E) + ovarian function suppression (OFS) or tamoxifen (T)+OFS


中文标题:SOFT与TEXT试验中绝经前激素受体阳性早期乳腺癌患者的15年结局:辅助依西美坦(E)+卵巢功能抑制(OFS)对比他莫昔芬(T)+OFS的获益评估


讲者:Prudence A. Francis, MD, FRACP | Peter MacCallum Cancer Centre


摘要号: 506

英文标题:Updated survival outcomes and predictors of benefit from ovarian function suppression in premenopausal women with hormone-receptor–positive breast cancer: Results from the ASTRRA trial


中文标题:更新生存结局及卵巢功能抑制对绝经前激素受体阳性乳腺癌患者的获益预测:ASTRRA试验结果


讲者:Jai Min Ryu, MD, PhD | Division of Breast Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine


摘要号: 507

英文标题:The impact of ovarian function suppression with adjuvant endocrine therapy on survival outcomes in young germline BRCA mutation carriers with breast cancer: Secondary analysis of an international cohort study


中文标题:辅助内分泌治疗联合卵巢功能抑制对年轻乳腺癌胚系BRCA突变携带者生存结局的影响:一项国际队列研究的二次分析


讲者:Paola Zagami, MD | UNC Lineberger Comprehensive Cancer Center/University of Milan/ European institute of Oncology IRCSS (IEO)




图片

更多学科专场信息陆续发布中……


读前沿进展,听中国强音,享国际视野。“2025ASCO年会中国医学论坛报学术联播”将持续关注大会动态,为大家带来大会最新内容,敬请期待!


整理自2025ASCO年会官网信息
编辑丨中国医学论坛报  桂晶晶

200 评论

查看更多