密码过期或已经不安全,请修改密码
修改密码壹生身份认证协议书
同意
拒绝
同意
拒绝
同意
不同意并跳过
内容提要:
1. 腹腔灌注化疗(IP)的药物选择
2. 紫杉醇IP的注意事项
3. VEGF抗体治疗恶性浆膜腔积液的进展
腹腔灌注化疗(IP)是一种腹腔恶性肿瘤辅助治疗手段。IP可以提高局部药物浓度,降低全身副反应。但腹腔灌注化疗的药物选择的考虑因素与化疗不同,除了药物的抑癌性,还需要考虑在腹腔的药物动力学和安全性。现临床较为常用的药物是紫杉醇类药物,同时,贝伐珠单抗和catumaxomab也是在探索中的腹腔灌注药物。
(最下方有课程中涉及的文献信息)
更多精彩内容,可下载壹生APP观看,或添加小助手微信号(13269296986,注明“恶性胸腹水”)咨询。
文献资料:
1. 李燕. 腹腔联合全身化疗治疗胃肠道恶性肿瘤并发腹腔积液81例[J]. 肿瘤研究与临床, 2009, 21(1):52-53.
2. Chen, D., et al., Greater efficacy of intracavitary infusion of bevacizumab compared to traditional local treatments for patients with malignant cavity serous effusion. Oncotarget, 2017. 8(21): p. 35262-35271.
3. Ferrara, N. and W.J. Henzel, Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. Biochem Biophys Res Commun, 1989. 161(2): p. 851-8.
4. Hamilton, C.A., et al., Intraperitoneal bevacizumab for the palliation of malignant ascites in refractory ovarian cancer. Gynecol Oncol, 2008. 111(3): p. 530-2.
5. Ishigami, H., et al., Phase III Trial Comparing Intraperitoneal and Intravenous Paclitaxel Plus S-1 Versus Cisplatin Plus S-1 in Patients With Gastric Cancer With Peritoneal Metastasis: PHOENIX-GC Trial. J Clin Oncol, 2018. 36(19): p. 1922-1929.
6. Kesterson, J.P., P. Mhawech-Fauceglia, and S. Lele, The use of bevacizumab in refractory ovarian granulosa-cell carcinoma with symptomatic relief of ascites: a case report. Gynecol Oncol, 2008. 111(3): p. 527-9.
7. Kobold, S., et al., Intraperitoneal VEGF inhibition using bevacizumab: a potential approach for the symptomatic treatment of malignant ascites? Oncologist, 2009. 14(12): p. 1242-51.
8. Miyamoto, K., et al., Disposition kinetics of taxanes in peritoneal dissemination. Gastroenterol Res Pract, 2012. 2012: p. 963403.
9. Numnum, T.M., et al., The use of bevacizumab to palliate symptomatic ascites in patients with refractory ovarian carcinoma. Gynecol Oncol, 2006. 102(3): p. 425-8.
10. Pichelmayer, O., et al., Bevacizumab is active in malignant effusion. Ann Oncol, 2006. 17(12): p. 1853.
11. Senger, D.R., et al., A highly conserved vascular permeability factor secreted by a variety of human and rodent tumor cell lines. Cancer Res, 1986. 46(11): p. 5629-32.
12. Sugarbaker, P.H., et al., Update on chemotherapeutic agents utilized for perioperative intraperitoneal chemotherapy. Oncologist, 2005. 10(2): p. 112-22.
13. Yamaguchi, H., et al., Breakthrough therapy for peritoneal carcinomatosis of gastric cancer: Intraperitoneal chemotherapy with taxanes. World J Gastrointest Oncol, 2015. 7(11): p. 285-91.
请您为本课程进行评价