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内容提要:
1. 腹膜转移的分期标准
2. 腹膜转移的综合治疗策略
3. 癌性腹水的对症治疗与系统化疗
大约10%的胃癌患者存在腹水,检出腹水大于50ml 的胃癌患者,腹膜转移的发生率高达75%以上,并且常伴有多种并发症,处理难度大。日本的一项回顾性研究证明有腹膜转移的胃癌患者预后显著降低。
而针对癌性腹水,现在尚无基于循证证据的治疗指南。
腹水是影响患者生存预后的核心因素之一。根据患者的情况,应选择合适的治疗方案,包括对症治疗、全身系统化疗及腹腔灌注化疗。
(最下方有课程中涉及的文献信息)
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文献资料:
1. 中国抗癌协会胃癌专业委员会.胃癌腹膜转移防治中国专家共识[J].中国医学前沿杂志,2017,9(5):p. 29-40.
2. Barnett, T.D. and J. Rubins, Placement of a permanent tunneled peritoneal drainage catheter for palliation of malignant ascites: a simplified percutaneous approach. J Vasc Interv Radiol, 2002. 13(4): p. 379-83.
3. Boku, N., et al., Fluorouracil versus combination of irinotecan plus cisplatin versus S-1 in metastatic gastric cancer: a randomised phase 3 study. Lancet Oncol, 2009. 10(11): p. 1063-9.
4. Chang, D.K., et al., Clinical significance of CT-defined minimal ascites in patients with gastric cancer. World J Gastroenterol, 2005. 11(42): p. 6587-92.
5. Iwasa, S., et al., Multicenter feasibility study of combination therapy with fluorouracil, leucovorin and paclitaxel (FLTAX) for peritoneal disseminated gastric cancer with massive ascites or inadequate oral intake. Jpn J Clin Oncol, 2012. 42(9): p. 787-93.
6. Koizumi, W., et al., S-1 plus cisplatin versus S-1 alone for first-line treatment of advanced gastric cancer (SPIRITS trial): a phase III trial. Lancet Oncol, 2008. 9(3): p. 215-21.
7. Maeda, H., M. Kobayashi, and J. Sakamoto, Evaluation and treatment of malignant ascites secondary to gastric cancer. World J Gastroenterol, 2015. 21(39): p. 10936-47.
8. Nashimoto, A., et al., Gastric cancer treated in 2002 in Japan: 2009 annual report of the JGCA nationwide registry. Gastric Cancer, 2013. 16(1): p. 1-27.
9. Nishina, T., et al., Randomized phase II study of second-line chemotherapy with the best available 5-fluorouracil regimen versus weekly administration of paclitaxel in far advanced gastric cancer with severe peritoneal metastases refractory to 5-fluorouracil-containing regimens (JCOG0407). Gastric Cancer, 2016. 19(3): p. 902-10.
10. O'Neill, M.J., et al., Tunneled peritoneal catheter placement under sonographic and fluoroscopic guidance in the palliative treatment of malignant ascites. AJR Am J Roentgenol, 2001. 177(3): p. 615-8.
11. Smith, E.M. and G.C. Jayson, The current and future management of malignant ascites. Clin Oncol (R Coll Radiol), 2003. 15(2): p. 59-72.
12. Yamada, Y., et al., Phase III study comparing oxaliplatin plus S-1 with cisplatin plus S-1 in chemotherapy-naïve patients with advanced gastric cancer. Ann Oncol, 2015. 26(1): p. 141-8.
13. Yonemura, Y., et al., A comprehensive treatment for peritoneal metastases from gastric cancer with curative intent. Eur J Surg Oncol, 2016. 42(8): p. 1123-31.
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