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恶性胸腔积液(MPE)是指原发于胸膜的恶性肿瘤或其他部位的恶性肿瘤转移至胸膜引起的胸腔积液,几乎所有肿瘤均可出现MPE,肺癌最常见,乳腺癌和淋巴瘤等也会导致MPE的出现。了解MPE的临床表现并进行诊断和规范化的治疗尤为重要。本节课刘红兵老师将为大家讲解恶性胸腔积液的诊断和传统治疗,下节课程会继续为大家讲解细胞因子药物治疗MPE的进展。
内容提要:
① MPE典型病例
② MPE的诊断路径
③ MPE的传统治疗方案
(最下方有课程中涉及的文献信息)
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文献信息:
1. 恶性胸腔积液诊断与治疗专家共识,中华内科杂志,2014,53(3):252-256
2. Oldem, Am, et al. Treatment of malignant pleural effusion: PleuRx catheter or talc pleurodesis? A cost-effectiveness analysis. J Palliate Med. 2010,13(1):59-65
3. Medford AR, et al. A national survey of oncologist and chest physicians' attitudes towards empirical anti-oestrogen therapy, early pleurodesis and preference of sclerosing agent in malignant breast and ovarian pleural disease. J Palliat Med,2005,19(5):430-431
4. Rahman NM, et al, Use of lipoteichoic acid-T for pleurodesis in malignant pleural effusion: a phase I toxicity and dose-escalation study. Lancet Oncol, 2008, 9(10):946-952
5. Seto T, et al. Intrapleural hypotonic cisplatin treatment for malignant pleural effusion in 80 patients with non-small-cell lung cancer: a multi-institutional phase II trial. Br J Cancer. 2006,95(6):717-721
6. Pleuritis carcinomatosa,Miyanaqa A,Gan Tokagaku Ryoho,2011,38(4):524-527
7. 张玉, 等. 恶性胸腔积液综合治疗进展[J]. 现代生物医学进展, 2012,12(17):3358-3361.
8. Becker G, et al. Malignant ascites: systematic review and guideline for treatment. Eur J Cancer. 2006, 42(5):589-597.
9. Roberts ME, et al. Management of a malignant pleural effusion: British Thoracic Society Pleural Disease Guideline 2010. Thorax. 2010, 65 Suppl 2:ii32-40.
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